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KMID : 0869220140180020076
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Journal of Korean Geriatric Psychiatry
2014 Volume.18 No. 2 p.76 ~ p.80
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Association between Cognitive Subdomains and Insight in Alzheimer Disease : A Clinical Research Center for Dementia of South Korea Study
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Kim Young-Don
Kim Sang-Ha
Myung Woo-Jae
Choi Jun-Bae
Yoon Hye-Yeon
Kang Hyo-Shin
Na Duk-Lyul
Kim Seong-Yoon
Lee Jae-Hong
Han Seol-Heui
Choi Seong-Hye
Kim Sang-Yun
Kim Doh-Kwan
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Abstract
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Objective： The aim of this study was to investigate the association between cognitive subdomains and insight into one’s cognitive impairment in patients with Alzheimer disease (AD).
Methods： We recruited 1,722 patients with AD from the Clinical Research of Dementia of South Korea study and designed a cross-sectional study. Each patient’s cognitive subdomain was assessed by using the Seoul Neuropsychological Screening Battery-Dementia version. Severity of dementia was evaluated by Korean version of Mini-Mental Status Examination (K-MMSE) and Clinical Dementia Rating Sum of Boxes (CDR-SB). Insight into one’s cognitive impairment was categorized as ‘with insight’ and ‘without insight’ through interview with patient’s caregivers.
Results：Among the 1,722 patients with AD, 1,475 patients were included in the ‘with insight’ group and the remaining 247 patients were included in the ‘without insight’ group. Subjects in the ‘without insight’ group had lower K-MMSE and CDR-SB scores than those in the ‘with insight’ group. After controlling for demographic data and dementia severity, higher scores on both attention function (odds ratio=1.12, 95% confidence interval : 1.03-1.21) and frontal-executive function (odds ratio=1.03, 95% confidence interval : 1.01-1.05) significantly predicted the membership to ‘with insight’ group.
Conclusion：In patients with AD, attention and frontal-executive function were associated with insight into one’s cognitive impairment.
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KEYWORD
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Alzheimer disease, Dementia, Cognitive function, Insight
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